Grapefruit juice–drug interactions
نویسندگان
چکیده
منابع مشابه
Grapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
متن کاملManagement of grapefruit-drug interactions.
Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. Characteristics of oral medications that may interact with grapefruit include extensive metabolism through the intestinal cytochrome P450 3A4 system, low bioavailability, and a narrow therapeutic index. Pro...
متن کاملGrapefruit-medication interactions: forbidden fruit or avoidable consequences?
action between grapefruit and certain medications more than 20 years ago. Currently, more than 85 drugs, most of which are available in Canada, are known or predicted to interact with grapefruit. This interaction en hances systemic drug concentration through impaired drug metabolism. Many of the drugs that interact with grapefruit are highly prescribed and are essential for the treatment of imp...
متن کاملAn overview of interactions between grapefruit juice and drugs
Because grapefruit contains fibre, vitamin C, antioxidants and phytochemicals, the fruit and its juice are consumed widely to help meet daily nutritional requirements. However, in the past 15 years, studies have shown that grapefruit juice can induce a several-fold increase in the plasma levels of particular drugs that can result in increased therapeutic or even toxic effects. The effect seems ...
متن کاملGrapefruit juice and drug interactions. Exploring mechanisms of this interaction and potential toxicity for certain drugs.
Concomitant administration of grapefruit juice can increase the plasma concentration of numerous drugs in humans and decrease the concentration of a few others. Such elevations of drug plasma concentrations have, on occasion, resulted in adverse clinical effects. Increased concentrations are primarily mediated by chemicals in grapefruit juice, which inhibit the CYP 3A4 drug-metabolizing enzyme ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1998
ISSN: 0306-5251,1365-2125
DOI: 10.1046/j.1365-2125.1998.00764.x